Amikacin

Protocol(s) for Sensitive Infections

• Our Recommendation: 10-15 mg/kg, IV/IM/ SC, q24h

• Dosing Interval: Amikacin is a concentration-dependent antimicrobial, and increased efficacy and decreased toxicity are proposed when higher doses are administered less frequently.  Where renal sensitivity is a consideration, increase dosing frequency to q36h or q48h (Matsumoto et al., 1982; Mayers et al., 1991; Staneva et al., 1994). 

• Hydration: Animals should remain well hydrated through treatment, and intravenous fluids are recommended in debilitated patients where practical.